Influence of a thin hpmc overcoating on drug dissolution before and after compression

摘要

Oral dosage forms with controlled release kinetics have become of growing interest in recent years. The polymer coating of drug-loaded particles has been an accepted method for controlling drug delivery. Such particles can then be either filled into hard gelatin capsules or compressed into tablets. However, numerous studies~1,2 have shown that coating films generally suffer from damages during compression proces,s leading to a loss of their sustained release characteristics. To protect polymer films from fracture under pressure, multilayered particles with cushioning excipient can be used.