The influence of cross-linkage and the nature of ligand bound to the surface of gliadin nanoparticles on the bioadhesion and pharmacokinetic relationships

摘要

The use of bioadhesive particulate drug delivery systems may improve the oral bioavailabiltiy of a number of lipophylic molecules. In this context, it has been described that the modification of the adhesive capacity may change the bioavailability of the loaded molecule in the dosage form~1. Two approaches can be used for modifying the bioadhesive properties of nanoparticles. The former may be the extent and the degree of the cross-linking process, which also increases the half-life of the system and modifies the drug release properties. The latter may be the binding of different molecules with bioadhesive potential, such as lectins and polycations, to of nanoparticulate surface in order to prepare the so-called conjugates. Therefore, the aim of this work was to study the influence of the cross-linking process and the nature of the molecule coating gliadin nanoparticles in the relationships between bioadhesion and pharmacokinetics.