Stratifying the risk of developing atrial fibrillation after coronary artery bypass graft surgery using heart rate asymmetry indexes

摘要

Heart period (HP) asymmetry (HPA) is a peculiar pattern detectable over short-term HP variability recordings suggesting that cardiac deceleration runs are shorter than acceleration ones in healthy subjects. We tested the hypothesis that two traditional HPA indexes, namely the Porta's index (PI) and Guzik's index (GI), can distinguish patients scheduled for coronary artery bypass graft (CABG) surgery developing atrial fibrillation (AF) after surgery from the ones who do not (noAF). HP was derived from the electrocardiogram in 130 patients scheduled for CABG before (PRE) and after (POST) the induction of general anesthesia. PI assesses the percentage of positive HP changes, while GI quantifies the percent sum of the squared positive variations. Positive departures from 50 suggest that a series exhibits HPA. Surrogate analysis was exploited to assess the significant presence of HPA patterns. The likelihood of detecting HPA patters was higher in AF subjects and this result held during PRE. GI featured a greater statistical power than PI. Neither HP mean nor variance distinguished the two groups. HPA indexes can be exploited to improve stratification of the risk for post-surgery AF.