Comparing reduced scattering variation by skin type and tissue location using Spatial Frequency Domain Imaging for clinical burn wound imaging

摘要

Spatial frequency domain imaging (SFDI), a noncontact imaging technique using structuredillumination with multiple wavelengths, has proved feasible for characterizing burns of different severitiesinduced in porcine dorsum. However, translation to human clinical subjects may be subject to variation intissue optical properties due to different skin types or body parts. To interrogate this potential difference inoptical properties, SFDI was used to measure the reduced scattering coefficient (μs’) in patients of varyingFitzpatrick skin type groups at 10 anatomical locations on the body. These scattering values were comparedagainst previously measured average μs’ values for burns in a porcine model. At 851nm, superficial partialthicknessburns had a 12.6% higher μs’ than unburned porcine dorsum. Deep partial-thickness and had 12.9%higher average μs’ than unburned porcine dorsum, while full-thickness burns had 2.5% higher average μs’than unburned porcine dorsum. The variation seen in scattering values at 851nm at one anatomical location(dorsal forearm) for the different skin type groups showed a 6.3% lower average μs’ in group 3 (skin types VVI)compared to group 2 (skin types Ⅲ-Ⅳ). Average scattering values were 3.8% lower in group 1 (skintypes Ⅰ-Ⅱ) compared to group 2 (skin types Ⅲ-Ⅳ). The variation of μs’ at 851nm across multiple anatomicallocations for the same skin type group (Group 1) was a 23% difference from the anatomical location with thehighest average μs’ at 851nm (forehead) to the lowest (shin). These findings indicate that furtherconsideration of skin type and location will be integral to the translation of classification techniques based μs’measurements of porcine dorsum to human patients.