Assessment of proton beam ablation in myocardial infarct tissue using delayed contrast-enhanced magnetic resonance imaging

摘要

External beam therapy has recently been proposed for treatment of ventricular tachycardia (VT). One of the goals of VT ablation is to eliminate myocardial channels by homogenizing infarct scar, thereby inhibiting reentry and eliminating VT. It has been previously shown that proton beam therapy can create lesions in healthy myocardial tissue, thereby suggesting a potential for treatment of VT. To date; however, the effects of proton beam energy in infarcted myocardial tissue is unknown. Tn the current work, we track proton beam dose maps in a series of delayed contrast-enhanced magnetic resonance imaging swine datasets across 16 weeks to assess the effects of proton beam ablation on infarcted myocardial tissue.