Microstructure, Corrosion and Cytotoxicity analysis of novel biodegradable Mg-Zn-Ca/HA alloys/composites for future biomedical applications

摘要

The present research work emphasizes on the study of micro-structure, corrosion and biological behaviour of novel Mg-(0-5)Zn-1Ca/(0-3)hydroxyapatite (HA) composites for future use as biomedical implantation. Microstructures showed a significant grain refinement with increasing Zn content along with HA agglomerates on the surface. Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) showed that Zn addition in Mg-1Ca alloy is assisting in inhibiting cathodic corrosion while HA addition in Mg-(0-5)Zn-1Ca alloy is increasing anodic corrosion along with Zn. Further, cytotoxicity analysis using direct and indirect contact methods were performed using L-929 cells, which showed that Zn addition (0-3 wt%) slightly increases cell viability and non-toxicity in Mg-1Ca alloy whereas a considerable improvement is observed after HA addition in Mg-Zn-1Ca alloys. Mg-1Zn-1Ca/3HA and Mg-3Zn-1Ca/3HA alloys/composites were observed to have controlled corrosion and non-toxic to L-929 cells.