A Portable Low-Power Platform for Ambulatory Closed Loop Control of Blood Glucose in Type 1 Diabetes

摘要

This paper presents a portable low-power platform that aims to maintain glycaemic control in people with type 1 diabetes. It runs on dedicated hardware, and incorporates a bio-inspired controller that replicates the insulin-secreting physiology of the pancreatic beta cells. The controller runs on an embedded microchip and the system has been optimized for low-power operation. The low-power, hand-held unit (BiAP) interfaces to a continuous glucose sensor (Dexcom G5) and sends the required insulin dose to a subcutaneous pump (Tandem t:slim). An adaptive meal bolus calculator running on an iPhone is used to improve the controller. The system architecture is presented in this paper along with the results of a 4 day hardware-in-the-loop test. The results show that the BiAP platform is robust and capable of achieving good control with no missed glucose values or device disconnections. Finally, the hand-held unit achieves power efficient operation, lasting for 6 days during full control.