Marker gene identification for gene expression analysis — Review and new findings for Diffused Large B Cell Lymphoma (DLBCL)

摘要

Cancer is a remarkable disease characterized with the de-regulation of various genetic pathways. The identification of gene markers, some of which carry signatures to clinical relevant physiological effects, sheds light on the development of various clinical applications. A major challenge in marker gene identification is the biological and statistical variability. In particular, we highlight state-of-the-art methodologies and the latest challenges in marker gene identification from gene microarray data. Moreover, we illustrate the use of a partial least square based approach for identifying gene markers from a Diffuse Large B Cell Lymphoma gene microarray dataset and present new findings.