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AUTOMATED NON-PREHENSILE MAGNETIC MICROMANIPULATION IN PRESENCE OF SPATIALLY VARYING FLOW FIELD

机译:存在空间变化流场的自动非圆环磁性微操纵

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摘要

Precise control of micro-level objects for cell sorting, cell manipulation, targeted drug delivery etc., still remains a great challenge in the field of bio-medical engineering. Even though magnetic actuation has emerged as a harmless, high actuation speed, low cost alternative for micromanipulation of cells, the throughput of the system is still low because of the undesirable effects of flow fields and sensing noise. This paper reports a parametrized feedback policy to perform non-prehensile magnetic micromanipulation to push the target cell to specified goal location under the influence of flow field, sensing noise, drag and magnetic forces. We report an optimization based parameter tuning approach to reduce the transport time using developed feedback policy. Flow field and image processing noise present in the system was experimentally measured and incorporated into the developed models and simulations. We have tuned the feedback policy parameter to reduce the travel time via simulation experiments.
机译:精确控制用于细胞分选,细胞操作,靶向药物递送等的微型对象,在生物医学工程领域仍然是一个巨大的挑战。尽管磁致动已经成为对细胞进行微操纵的无害,高致动速度,低成本的替代方案,但由于流场和感应噪声的不良影响,系统的吞吐量仍然很低。本文报道了一种参数化的反馈策略,该策略执行非精确的磁性微操纵,以在流场,感应噪声,阻力和磁力的影响下将目标细胞推至指定的目标位置。我们报告了基于优化的参数调整方法,以减少使用开发的反馈策略的运输时间。对系统中存在的流场和图像处理噪声进行了实验测量,并将其纳入已开发的模型和仿真中。我们已经通过模拟实验调整了反馈策略参数,以减少旅行时间。

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