Developing a robust colorectal cancer (CRC) risk predictive model with the big genetic and environment related CRC data

摘要

Currently, colorectal cancer (CRC) already becomes one of the most common cancers worldwide. Though the prognosis of CRC patients is dramatically improved due to the new advanced treatments and medical improvements, the 5-year survival rate for the CRC patient is still low. Thus, we hypothesize that CRC may result from the complicated reasons related to both genetic and environmental factors. For this reason, this study collects such big CRC data with information of genetic variations and environmental exposure for the CRC patients and cancer-free controls that are employed to train and test the predictive CRC model. Our results demonstrate that (1) the explored genetic and environmental biomarkers are validated to cause the CRC by the manually reviewed experimental evidences, (2) the model can efficiently predict the risk of CRC after parameter optimization by the big CRC-related data, (3) our innovated generalized kernel recursive maximum correntropy(GKRMC) algorithm has high predictive power. Finally, we discuss why the GKRMC can outperform the classical regression algorithms and the related future study.