EVALUATION OF GENE EXPESSION CHANGES IN HUMAN PRIMARY LUNG EPITHELIAL CELLS FOLLOWING 24-HR EXPOSURES TO INORGANIC ARSENIC AND ITS METHYLATED METABOLITES AND TO ARSENIC TRIOXIDE

摘要

1. Defining the shape of the dose-response curve in the low-dose region (linear versus nonlinear) 1.1 Epidemiological studies - do not provide a clear indication of the concentration at which no adverse effects from arsenic exposure are expected, nor do they inform the shape of the dose-response curve (linear versus nonlinear) at low arsenic concentrations in drinking water 1.2 Animal studies - studies conducted to date have relied on the administration of arsenic concentrations as high as or higher than those anticipated in human populations. 1.3 Mode of Action studies - an extensive database is available, but no attempt to integrate and understand mode of action. NAS (2013) Committee noted the importance of these studies in understanding: 1.3.1 Extrapolation below the observed range. 1.3.2 Interhuman variability and consideration of this data to guide modeling qualitatively in the low dose region. 1.3.3 Modeling in the low dose region In considering susceptibility even if the mode of action cannot be firmiy established.