Genome-Wide Association Study (GWAS) on Metabolic Syndrome in Subjects with Abdominal Obesity in a Taiwanese Population.

摘要

Granted that the association of SNPs with metabolic syndrome (MetS) has been reported in diverse populations including Taiwanese, the relationship between abdominal obesity and metabolic syndrome still be vague. In this GWAS study, we assessed SNPs that are associated with MetS in subjects with abdominal obesity. A total of 10,285 Taiwanese subjects were evaluated in this study. We found the association of MetS with three significant SNPs located on different chromosomes at the genome-wide significance level (P <; 8.6 × 10^{-8). The rs662799 SNP in the apolipoprotein A5 (APOA5) gene, the rs325 SNP in lipoprotein lipase (LPL) gene, and the rs247617 SNP in Cholesteryl Ester Transfer Protein (CETP) gene. Also, we surprisingly discovered that the rs325-C and rs247617-A are protective factors and the rs662799-G is a risk factor for subjects with abdominal obesity. Our results supported the APOA5, LPL, and CETP genes that may contribute to the risk of metabolic syndrome in a Taiwanese population.}