NEURONAL PRECURSOR CELL PROLIFERATION ON ELASTIC SUBSTRATES

摘要

This study is the first to show matrix elasticity affects culture composition and NPC proliferation from primary SCNs. We first showed that the percentage of NPCs increased as matrix elasticity increased, while the percentage of neurons decreased. Next, we proved these results are partly due to NPC proliferation on stiffer matrices. In conclusion, NPCs proliferate on stiffer matrices agrees with previous literature showing bone marrow-derived mesenchymal stem cells remain quiescent on soft substrates [8].