Nanoparticles that facilitate imaging of biological tissue and methods of imaging (Systems and methods for biological 21 Tesla Magnetic Resonance Imaging of heart)

摘要

A superparamagnetic nanoparticle (SPIOM) containing antimyoglobin coated and polyethylene encapsulated biotin-avidin-iron-oxide core in center may be provided according to an example embodiment of the invention. These nanoparticles may be used as imaging contrast agents due to their dephasing and susceptibility effect on NMR relaxation relationship. High resolution rat heart images after SPIOM injection may be acquired at 21 Tesla MR microimaging (or similar imaging) by rapid 3D fast low angle shot (FLASH) and 3D gradient echo flow compensated (GEFC) and mutislice multiecho (MSME) MR imaging of excised or intact cardiac structures may be optimized for their visualization. The rat heart images may be processed for the measurement of cardiac wall, ventricle volume, aorta, possible orientation details of cardiac myofibrils tissue and cardiac atlas, according to example embodiments of the invention. The microimaging details of cardiac structures were compared by histology and matched cardiac structures on MRI images after segmentation. A feasible approach of quantitative cardiac shape, texture and motion analysis is described herein with possible implications.