A two-phase flow hemorhcological model for blood was developed to predict the RBC-plasma phase separation. Constitutive equations with material parameters based on volume fraction were derived for both RBC and plasma phases and introduced into the governing equations for mixture theory. Theresults showed a distribution of RBCs with a diminished near-wall concentration, which is consistent with experimental observations. The two-phase model also predicted interaction forces that be able to move RBCs away from the wall. The results imply two-phase blood model based on mixture theory is a promising approach to better predict hemorhcological phenomena relevant to blood trauma.In the current simulation, the lateral concentration gradient of RBCs was not as great as experimental observations. This probably because the material paramters used in the interaction forces are too small. The focus of the ongoing work is to improve the model performance by seeking more appropriate form/value of material parameters.
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