Investigation of multifunctional cell physiological analysis instrument based on integrated chip

摘要

This paper describes a novel multifunctional cell physiological analysis instrument based on integrated chip.And we introduces a novel cell sensors chip which integrated MEA,ECIS and light addressable potentiometer sensors (LAPS) which is designed for the purpose of detecting the cell physiological parameters.The instrument has been integrated with a multi-channel high precision open circuit potential measurement system for micro electrode array as well as a potentiostat in ECIS.And an analog lock-in amplifier is also presented to measure the response of LAPS.In addition,in order to achieve multiple analysis,we first tested every parameters of the chip,then we raise different cells on the surface of the chip.The result shows that such biosensors have numerous applications including pharmaceutical screening,cellular physiological analysis,toxin detecting,peripheral nerve regeneration and environment monitoring.