An Approach for Fabrication of Polymer-based Bio-analytical Microfluidic Devices

摘要

This research performed on the fabrication of thermal bonding of polymer microfluidic devices. Hot embossing process and thermal bonding were both achieved. Fine replication by micro hot embossing using polycarbonate substrate has been modified. Nanoscan machine using optical technique can be used to analyze the fabricated microstructures. Hot embossing results show that the near perfect replication of microstructure has been demonstrated, and the shrink degree of the geometry is less than 3%. The two stage process of thermal bonding was performed. The advantage of this method is to prevent the channel filled with the cover plate. The bond strength of the interface for the micro channel is greater than 17MPa using pull test method. The best results were able to seal the microstructure and drilled hole properly and allow for fluids to flow through channel from one reservoir to another one.