The Comparative Study and Evolution of SARS Coronavirus and Other Coronaviruses

摘要

The cause of acute respiratory syndrome (SARS) has been identified as a new coronavirus. Whole genome sequence analysis of several isolates of the coronavirus has also been completed. Comparisons of the genomes of SARS coronavirus (SARS - GoV) and other coronaviurses indicated that the sequences of polymerase are most closely related to bovine and murine coronavirus in Group Ⅱ with some characteristics like avian viruses in Group Ⅲ , and suggested that SARS - CoV should be classified in a new coronavirus group, In this study, we try to identify that which group of known coronavirus is most closely related to SARS - CoV in function and structure, what kind of phylogenetic relationship among all known coronavirus groups and SARS - CoV and the origin of SARS - CoV.