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Trilinear Models for Batch MSPC: Application to an Industrial Batch Pharmaceutical Process

机译:用于批处理MSPC的三线性模型:在工业批处理制药过程中的应用

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In this paper, PARAFAC and Tucker3 models were compared with the commonly used multiway principal components analysis approach (MPCA) for multivariate process control of an industrial batch antibiotic production process. Two different approaches for on-line monitoring were used: sliding window (multiple models) and global window (single model) monitoring strategies. The later approach requires orthogonality for the time dimension scores. In this context, a modification of the Parafac algorithm was proposed. The Tucker3 and Parafac models as proposed here share an identical structure. Scores (D) and residuals (Q) statistics were used to on-line identify faults. We concluded that Parafac and Tucker3 models outperformed MPCA in terms of detection of faults specially when the statistic for scores is used. All models performed equally well in the residuals statistics. The sliding window strategy proved to be more appropriate to identify faults than the global window strategy. This is, to our best knowledge, the first time such study was performed for an industrial batch antibiotic process.
机译:在本文中,将PARAFAC和Tucker3模型与用于工业批生产抗生素过程的多过程控制的常用多路主成分分析方法(MPCA)进行了比较。使用了两种不同的在线监视方法:滑动窗口(多个模型)和全局窗口(单个模型)监视策略。后一种方法要求时间维度得分具有正交性。在这种情况下,提出了对Parafac算法的修改。这里提出的Tucker3模型和Parafac模型具有相同的结构。分数(D)和残差(Q)统计信息用于在线识别故障。我们得出的结论是,就检测故障而言,Parafac和Tucker3模型的性能优于MPCA,特别是在使用分数统计信息时。所有模型在残差统计中的表现均相同。事实证明,滑动窗口策略比全局窗口策略更适合于识别故障。据我们所知,这是首次针对工业批量抗生素工艺进行此类研究。

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