Influence of surface-modifying surfactants on the pharmacokinetic behavior of ~14C-poly (methylmethacrylate) nanoparticles in tumor models with different angiogenesis

摘要

Macromolecular or colloidal drug carriers such as polymer drug conjugates, liposomes, and nanoparticles are rapidly gaining importance for the therapy of solid tumors~1,2 due to the EPR (enhanced permeability and retention) effect~3,4. The objective of the present study was to investigate the influence of the surface properties of vesicles on the transport of particles into different tumors. Polymethyl(2-~14C) methacrylate nanoparticles were used in combination with three surfactants, i.e. polysorbate 80, poloxamer 407, and poloxamine 908. Uncoated nanoparticles served as controls. Three tumor models were chosen, different in growth, angiogenesis, origin and localization.