Formulation of a bioadhesive bilayered buccal tablet of natamycin for oral candidiasis

摘要

Candidiais induced by Candida albicans is the most common fungal infections of the oral cavity in humans. Topical delivery of antifungal agents within the oral cavity is the most widely accepted approach with techniques aimed at prolonging drug concentrations in the oral cavity. Conventional dosage forms would be the simplest dosage form for the delivery of drugs through the mucosa or to the oral cavity. The main disadvantage of suc dosage forms is an initial burst of activity followed by a rapid decrease in concentrations below therapeutic levels. Oral candida infections require prolonged therapy with antifungal agents. In order to increase the residence time of drugs for local therapy in the oral cavity, several bioadhesive systems have been developed in recent years.