Anticryptosporidial activity of bupravaquone and improving its in vivo efficacy by the formulation as a mucoadhesive nanosuspension

摘要

Cryptosporidium parvum is a protozoan parasite associated with municipal water suppleis which causes diarrhea. In patients with a normal immune system, the disease manifests itself with watery diarrhea, cramps, nausea and anorexia. In immunocompromised people, such as those receiving immunosuppressant drugs or those infected with HIV-1, symptoms are more severe (10-15 percent of patients with AIDS in the United States may acquire cryptosporidium infection). The disease is prolonged, and diarrhea can persist for months, even years. There is no specific treatment for cryptosporidiosis.