Investigation of surface and drug release of solid lipid nanoparticles loaded with aciclovir

摘要

Solid lipid nanoparticles (SLN) are a particulate carrier system alternative to polymer nanoparticles or liposomes. SLN have the advantage of biodegradability, low toxicity and low costs in production. They consist of physiological biocompatible lipids, which are suitable for the incorporation of lipophilic, hydrophilic and poorly water soluble active ingredients. Limited data are reported about structure, particle order and crystallinity of loaded and unloaded SLN. The physical structure influences stability, amount of incorporated drugs and drug release. The aim of this study is the incorporation of the model drug aciclovir in SLN and the determination of its influence on the properties of the matrix. This shall be investigaged by transmission electron microscopy (TEM), atomic force microscopy (AFM) and small angle X-ray scattering(SAXS).