Brain response to photodynamic therapy and Photofrin nonsulfonated aluminum phthalocyanine and tin purpurin

摘要

Abstract: Photodynamic therapy (PDT) with Photofrin$+R$/, nonsulfonated aluminum phthalocyanine (AlClPc), and tin ethyl etiopurpurin I (SnET2) was investigated on normal and tumored (9L gliosarcoma) rat brain. Rats were injected 48 h prior to PDT (3 - 280 J/cm$+2$/, 100 mW/cm$+2$/) with Photofrin$+R$/ (12.5 mg/kg) and AlClPc (2.0 mg/kg) and 24 h prior with SnET2 (1.0 mg/kg). Substantial lesions were present in normal brain with Photofrin$+R$/ and with AlClPc at all energy levels. No lesions were present with SnET2. Tumor response for Photofrin$+R$/ and AlClPc did not occur with doses less than 140 J/cm$+2$/. Drug concentrations for tumored/contralateral hemisphere for Photofrin$+R$/ and AlClPc were 1.86 and 7.86, respectively. These data indicate: (1) normal brain is more sensitive than the tumored brain with Photofrin$+R$/ and AlClPc, and (2) normal brain sensitivity to SnET2 is less than that with Photofrin$+R$/ and AlClPc. !0