Increased throughput for process chromatography using constrained deconvolution

摘要

Signal restoration using Jansson's method of constrained deconvolution was investigated and tested to deconvolve and thereby resolve severely overlapped gas chromatographic peaks. The results of this technique were compared to what can be obtained with an instrument that uses a longer column that already produces fully resolved peaks. Jansson's deconvolution method enables significant resolution improvement at minimal cost in computation time. Thus, for a given amount of peak resolution, this technique greatly increased the instrument's throughput. Test results show throughput increases of 10 times. Test results also show that Jansson's method provides measurement accuracies and variances similar to those obtained on an instrument that uses a longer column to achieve peak resolution.