Microplate Agar (MPA) - A Promising Miniaturized Protocol for the Ames Test

摘要

We concluded that the MPA technique was successful in identifying mutagenicity of new compounds using less than 20 mg of test specimen and 6 different strains with and without metabolic activation. Its application saved time, money and material, in comparison to the standard Ames test. We believe that this MPA approach can be used for the testing of new biomaterials, including their precursors, leachables and extractables, and so provide early identification of their potential mutagenicity.