On-Demand Pressure-Driven Molecular Release for Active Anti-oxidization

摘要

This study demonstrates an active antioxidizing polymeric particles that can increase the internal pressure in response to the abnormal ROS level and thus actively discharge antioxidants to protect cells and tissues from oxidative damage. The active antioxidant-releasing particle was assembled by simultaneously loading MnCh nanosheets and green tea-derived antioxidants into PLGA particles. The MnO_2 nanosheets in the core of PLGA particle steadily decomposed H_2O_2 and generated O_2 gas that can act as a pressurizer. Accordingly, the active antioxidizing particle system could release a larger fraction of antioxidants and effectively protect endothelial cells and brain tissues from H_2O_2-induced oxidative damage. Therefore, we expect that this study would significantly impact the current design paradigm of controlled molecular releasing systems and subsequently improve the efficacy of a broad array of molecular cargos.