We have described mechanical and biotransport characterization of a GelMA hydrogel system during MSC-mediated remodeling. Elastic and shear moduli, diffusivity and mesh size, were found to follow similar trends. Preferential regimes of HSC maintenance were established as dependent on hydrogel properties as well as the presence of a critical niche cell (MSCs). MSC matrix remodeling indicates a temporally changing biomaterial landscape. Ongoing efforts will characterize the dynamic interplay between local mesh architecture and domains of paracrine and autocrine signaling.
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