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In Vivo Detection of Cancer Stem Cells by Dual Mode CT/Fluorescence Using Immunotargeted Nanoparticle Probes

机译:使用免疫靶向纳米粒子探针通过双模式CT /荧光体内检测癌症干细胞

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Au@SiO_2(Cy5)-anti-CD133 NPs exhibited immunotargeting and enabled contrast-enhanced detection of CD133(+) ovarian cancer cells by fluorescence and CT in both in vitro cell and in vivo tumor models. The modular approach used to assemble immunotargeted core-shell NPs can be readily extended to include other targeting molecules, therapeutic molecules, and imaging modalities.
机译:Au @ SiO_2(Cy5)-抗CD133 NPs表现出免疫靶向性,并能够通过荧光和CT在体外细胞和体内肿瘤模型中对比检测CD133(+)卵巢癌细胞。用于组装免疫靶向的核壳NP的模块化方法可以很容易地扩展到包括其他靶向分子,治疗性分子和成像方式。

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