Microfluidic Poly(ethylene glycol)-based Islet Encapsulation Enables Transplantation in Highly Vascularized Site

摘要

Microfluidic PEG-based islet encapsulation reduces capsule diameter to improve insulin transport kinetics over gold standard alginate control encapsulated islets in vitro and in vivo, resulting in a reduced islet loading requirement in a syngeneic murine model of diabetes, and enabling transplantation into a retrievable and highly vascularized graft site. Importantly, we demonstrate that reduced capsule diameter does not impede efficacy of immunoisolation to protect the graft from allo- and autoimmune responses.