An antigen-specific microparticle system blocks experimental autoimmune encephalomyelitis

摘要

In the present study, we have demonstrated that a combinatorial dMP system can modulate immunity in an antigen-specific manner to block disease onset in the mouse model of MS. Successful therapeutic intervention with the dMP required encapsulation of disease-relevant antigen and encapsulation of factors in degradable microparticles. Mechanistic studies to elucidate precise tolerogenic pathways are ongoing, however, ex vivo re-stimulation assays suggest deletion of MOG_((35-55)) autoreactive T cells or induction toward an anergic state as potential mechanisms.