25 years have passed since 1993 when CNES conceived and constituted CADMOS, the French acronym for "Centre for Development of Activities in Microgravity and Space Operations". CADMOS was created as a CNES department charged with performing and promoting all the activities linked to human spaceflight and microgravity science. CADMOS activities started with three nominal flights on-board of the Russian Space Station MIR and continued on-board of the US space shuttle. When in 2001 ESA started looking for the future organisation of the incoming European own human spaceflight and microgravity operations, CADMOS was selected as one of the 9, at that time, European USOCs (User Support Operations Centre), with a field specialisation in human physiology and responsible for the European Physiology Module (to be uploaded on-board of the ISS) and almost all the related operations. In the last fifteen years, CADMOS has seen the field of expertise being enlarged in the frame of human physiology, new bilateral collaboration being established and successfully operated, new payloads assigned, the starting of a new developping field in fundamental physics with the assignments of ACES operations. New payloads operations in the frame of fundamental and material science for the long-lasting Plasma-Kristall experiment has reached version number 4. When in 2014 the mission PROXIMA associated with the French Astronaut Thomas Pesquet was rolled out, CADMOS took the initiative of preparing several payloads and experiments to be operated during the 6-month flight. To prepare PROXIMA mission, CNES/CADMOS conceived and developed 7 experiments with associated payloads, ranging from human physiology to life support and fluid mechanics. This development was done using a highly integrated environment with an agile approach. After the end of the PROXIMA mission, this strategy has shown a very high payoff in terms of return on investment and accomplishment of the targetted results. This is giving an outlook on possible ways for approaching future activities. Within a changing human spaceflight world, with the recent announcement from ESA to reduce the number of USOCs, there are opportunities for enlarging the scope of CADMOS activities giving an overall contribution to the European participation to human spaceflight and more largely to space exploration.
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