Prediction of Protein-Protein Interaction Sites Combing Sequence Profile and Hydrophobic Information

摘要

Identification of the residues in protein-protein interaction sites has an important impact in a lot of biological problems. We propose an extra-trees method to identify protein interaction sites in hetero-complexes by combing profile and hydrophobic information based on extra-trees. The efficiency and the effectiveness of our proposed approach are verified by its better prediction performance compared with other methods. The experiment is performed on the 1250 non-redundant protein chains. Without using any structure data, we only use profile and a binary profile hydrophobic attribute as input vectors.