Cell-Seeded Synthetic Scaffold for Esophageal Regeneration

摘要

Conclusions. We describe an innovative bioengineeered construct that combines autologous cells with a synthetic scaffold for the treatment of patients with esophageal disease. The results demonstrate the feasibility of this approach to facilitate the regeneration of full thickness circumferential defects after esophageal resection as would be clinically required for esophageal malignancy. In addition to the esophagus, we expect the same approach to help patients with disorders of other hollow organs, such as the trachea and bronchus.