Imaging of nanoscale particles in microfluidic devices using super-lens manipulated by optically-induced dielectrophoresis

摘要

Microsphere-assisted microscopy is a recent super-resolution microscopy technique that is a simple but effective approach to resolve features two to four times smaller than the diffraction limit. However, it is still a difficulty to place high-refractive-index microspheres-based super-lens at a specific site of interest, especially inside microfluidic devices. Here, we demonstrate a flexible and cantilever-free method for transporting a microsphere super-lens to a specific site of interest inside a confined microfluidic environment using optically-induced dielectrophoresis. By such method, nanoparticles and subwavelength features of interest can be observed in real-time and large field-of-view super-resolution images can be obtained inside microfluidic devices.