PUEPro: A Computational Pipeline for Prediction of Urine Excretory Proteins

摘要

A computational pipeline is developed to accurately predict urine excretory proteins and the possible origins of the proteins. The novel contributions of this study include: (i) a new method for predicting if a cellular protein is urine excretory based on unique features of proteins known to be urine excretory; and (ii) a novel method for identifying urinary proteins originating from the urinary system. By integrating these tools, our computational pipeline is capable of predicting the origin of a detected urinary protein, hence offering a novel tool for predicting potential biomarkers of a specific disease, which may have some of their proteins urine excreted. One application is presented for this prediction pipeline to demonstrate the effectiveness of its prediction.