Growth Factor Release from poly(ethylene glycol) diacrylate Hydrogels as a Treatment for Chronic Wound Healing

摘要

There was no significant difference in cell viability between sheet and microsphere hydrogels: however, the release of FGF-7 from hMSCs encapsulated in sheets was significantly lower. The greater surface area of the microspheres may allow for factors to more easily diffuse from the encapsulated cells to the surrounding media. Alternatively, the relatively violent process of encapsulating cells within microspheres may have stimulated the hMSCs into releasing more FGF-7 than hMSCs encapsulated under the gentle conditions required to form hydrogel sheets. Future work will include microencapsulations for cells that will ultimately be encapsulated in hydrogel sheets. In addition, assays will be performed to detect other crucial growth factors in wound healing, such as vascular endothelial growth factor and epidermal growth factor.