Antibody-targeting of Drug-loaded Micelles to Acute Myeloid Leukemia Cells

摘要

Antibody targeting greatly enhanced the ability of PSMA-b-PS micelles to bind CD123 positive cells in vitro. Homing of PTL-loaded micelles has not significantly enhanced PTL cytotoxicity compared to untargeted micelles in vitro, but may drastically improve PTL efficacy in vivo due to increased bioavailability and LSC-specific delivery. Future studies will focus on PTL delivery mechanisms of targeted and non-targeted micelles, and the ability to reduce off-target drug accumulation in mixed primary cell culture systems.