Polyanhydride Nanovaccines Elicit Protective Virus Neutralizing Titers and Cell-mediated Immunity Against Influenza

摘要

The studies herein demonstrate the strong immunogenic properties of the H5_3 antigen. All formulations displayed neutralizing antibody titers similar to a MPLA-adjuvanted control, while the poly I:C + nanovaccine formulation enhanced CD4~+ T cell proliferation. Upon challenge with a live virus, H5_3-vaccinated mice were protected laying a foundation for the polyanhydride nanovaccine platform in developing influenza vaccines.