Magnetic Targeting of Human Aortic Smooth Muscle Cells for Rapid Closure and Healing of Intracranial Aneurysm/Pseudoaneurysm

摘要

The aneurysm/pseudoaneurysm treatment requires a complete and definitive occlusion of the deffect from the parental artery to prevent bleeding. Current approaches such as coil embolization are still suboptimal for aneurysm sac occlusion, exhibiting various documented postsurgery recurrences. Asymetric bioactive stents with a magnetic surface able to attract magnetized cells may promote a rapid aneurysm treatment by bringing the aneurysm neck. An efficient cell internalization of nanoparticles is a perrequisite to address the feasiability of these approaches. In this study, cell magnetization using low pulse and low voltage electroporation parameters are assessed, and their effects on cell viability, genotoxicity, and nanoparticle internalization are shown.