Osteogenic potential of a silicate-substituted calcium phosphate bone graft substitute seeded with human periosteal mesenchymal stem cells an in vitro and in vivo assessment

摘要

These results suggest that although Actifuse? alone could induce ectopic bone formation, combining human Pe-MSCs with Actifuse? granules can significantly enhance bone formation. This could be a new therapeutic strategy to improve bone regeneration for patients. Ion dissolution from Actifuse? microgranules enhanced osteogenic differentiation, as measured by ALP activity, of Pe-MSCs in vitro, and this mechanism may be involved in the bone formation process.