Effectiveness research of deep brain stimulation operation for patients with Parkinson's disease based on polar coordination system with varied origin

摘要

Parkinson's disease (PD) is a common disease of central nervous system among the elderly, and its complex symptoms bring up some difficulties for the clinical diagnosis. And Deep Brain Stimulation (DBS) is an effective treatment method for patients with Parkinson's disease. In this study, a method based on polar coordination system with varied origin was proposed to quantitatively evaluate the availability of DBS operation for patients with Parkinson's disease. Totally, seven patients with Parkinson's disease were participated in the spiral drawing experiment and their scores under Unified Parkinson's disease Rating Scale (UPDRS) were also recorded. According to the characteristics of hand movement in spiral drawing, a set of parameters were defined and calculated before and after DBS operation. Compared with the UPDRS scores, experimental results showed that this method of evaluation was consistent with the clinical diagnosis. The proposed method based on polar coordinate system with varied origin is effective in clinical diagnosis, and it provides a basis for quantitative evaluating the effectiveness of surgery and treatment.