Viability and Differentiation of BMP-2 on W-20-17 cells in the Presence of Vancomycin.

摘要

The range of vancomycin and BMP-2 tested was selected based on elution studies from bone scaffolds in the laboratory. While there was not an overt cytotoxic effect of the test solutions on the cells, all mock eluates that contained vancomycin did result in a suppression of ALP by the W-20-17 murine cells as compared to BMP-2 mock solutions that did not contain any vancomycin. This indicates that released vancomycin levels may interfere with BMP-2 stimulated osteogenesis.