Synthesis and Characterization of Poly(Antioxidant p-amino Esters) for Delivery of Polyphenolic Antioxidants

摘要

Antioxidants quercetin and curcumin were successfully incorporated into poly(p"-amino ester) backbone. Degradation rate of PABAE is tunable thereby allowing sustained and controlled release rate of antioxidants. Degradation products of PABAEs possessed antioxidant function demonstrated by suppression of DCF fluorescence in a cell based oxidative stress model. This capability of PABAEs to modulate RedOx state of the cells has far reaching implications in use of antioxidant polymers as a means to control cell behavior for a variety of biomedical, pharmaceutical, and tissue engineering applications.