A biodegradable, non-thrombogenic elastomeric poly(ester urethane)urea with paclitaxel release as a drug eluting stent coating

摘要

A biodegradable elastomeric poly(ester urethane)urea was synthesized that incorporated non-thrombogenic pendant groups and possessed attractive mechanical properties for coating applications. The new polymer exhibited markedly reduced platelet deposition as well as the capacity for paclitaxel controlled release. This biomaterial may find application as a drug-eluting coating for metallic vascular stents or as a scaffold for vascular tissue engineering applications where minimal acute thrombogenicity is required.