Rationale design of multi-functional nonviral gene delivery vector for antitumor therapy

摘要

Newly designed gene delivery system possessing multiple functional domains such as linear polyethylene glycol (PEG), cyclic NRG (CNGRCK, cNGR) tumor-targeted peptide and bioreducible branched polyethylenimine (BPEI) was synthesized and evaluated with respect to the combining effect of targeting and intracellular reducible functions concerning gene transfection in various cancer cells.