Gastric Retentive System for Sustained Release of Metformine HCl Combined with ImmediateRelease of Pioglitazone HCl

摘要

Metformine HCl has been used for Diabetic MellitusType II and absorbed mostly in upper gastrointestinaltract more than 70% approximately. Pioglitazone HCl ispractically insoluble in water and once a daily dose isrecommanded. Thus, the combination therapy for DMshould be taken into consideration at the pharmaceuticalpoint of view. Metformine HCl was coated withbioadhesive polymer and granulated/blended withsustained hydrophilic polymer containg gastric retentivecomponents, which manipulate the release limiting stepand give the modified drug release keeping floating formore or less 6 hours. The analysis methodology for freelysoluble drug and practically insoluble drug was validatedsimultaneously in this study.