Biomanufacturing of Microcapsules for Drug Delivery and TissueEngineering Applications

摘要

This paper presents a biomanufacturing approach for generating bio-polymer microbeads that can be used forlocalized drug delivery and tissue engineering applications. Calcium alginate microbeads were produced usingspecialized micro jetting technique with tight size distributions. The rheological properties of the polymer werestudied to gain a better understanding of the fluid's behavior during the jetting process. A designed experiment withmultiple levels of bio-polymer concentrations was conducted to ascertain the significant factors affecting thediameter and stability of the microbeads. This study demonstrates a method of utilizing specialized micro jettingtechnology to manufacture consistent microbeads for variety of biomedical applications.