A Cremophor-Free Formulation for 17-AAG using PEO-b-PDLA Micelles: Characterization and Pharmacokinetics in Rats

机译：使用PEO-B-PDLA胶束的17-AAG的一种Remophor的配方：大鼠表征和药代动力学

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A Cremophor R-free formulation of the geldanamycin analogue 17-AAG was prepared using amphiphilic block co-polymer micelles of poly(ethylene oxide)-b-poly(d-lactic acid) (PEO-b-PDLA). Rats were dosed intravenously with PEO-b-PDLA micelles and a standard formulation of 17-AAG as control. The area under the curve, volume of distribution, and mean residence time increased. Total clearance of the drug decreased.

机译：使用聚（环氧乙烷）-B-聚（D-乳酸）（PEO-B-PDLA）的两亲嵌段共聚物胶束制备Geldanamycin类似物17-AAG的Cremophor R-AAG。大鼠用PEO-B-PDLA胶束静脉内给药，并作为对照的标准配方。曲线下的面积，分布体积和平均停留时间增加。药物的完全清除减少了。

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《Controlled Release Society Annual Meeting and Exposition》|2007年||共2页
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May P. Xiong; David Hart; Neal M. Davies; M. Laird Forrest;
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中图分类生物工程学（生物技术）;
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4. A Cremophor-Free Formulation for 17-AAG using PEO-b-PDLA Micelles: Characterization and Pharmacokinetics in Rats [C] . May P. Xiong, David Hart, Neal M. Davies, Controlled Release Society Annual Meeting and Exposition . 2007

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A Cremophor-Free Formulation for 17-AAG using PEO-b-PDLA Micelles: Characterization and Pharmacokinetics in Rats

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