Pharmacokinetic Modeling to Improve the Design of Intravitreal Corticosteroid Implants for Treating Macular Edema

机译：药物动力学模型可改善玻璃体皮质类固醇植入物治疗黄斑水肿的设计

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A pharmacokinetic model of ocular drug concentrations from sustained-released corticosteroid implants was derived from Fick's 2~(nd) Law and summated diffusion coefficients. The model predicted that more posteriorly placed implants in the vitreous humor would increase drug concentrations at the macula, and decrease concentrations in the aqueous humor.

机译：根据Fick的2〜（nd）定律和求和的扩散系数，得出了缓释皮质类固醇植入物的眼药浓度的药代动力学模型。该模型预测，在玻璃体液中放置更多的后置植入物会增加黄斑处的药物浓度，并降低房水中的浓度。

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《Controlled Release Society Annual Meeting and Exposition》|2007年|P.310-311|共2页
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Susan S. Lee; David Z. DArgenio; Rex A. Moats; Joan-En Lin; Devin F. Welty; Patrick Hughes; Scott M. Whitcup; Michael R Robinson;
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中图分类生物工程学（生物技术）;
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4. Pharmacokinetic Modeling to Improve the Design of Intravitreal Corticosteroid Implants for Treating Macular Edema [C] . Susan S. Lee, David Z. DArgenio, Rex A. Moats, Controlled Release Society Annual Meeting and Exposition . 2007

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Pharmacokinetic Modeling to Improve the Design of Intravitreal Corticosteroid Implants for Treating Macular Edema

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